Prof. Brian Lithgow
University of Manitoba, Monash Alfred Psychiatry Research Center
Speech Title: Electrovestibulography: A methodology utilizing electrophysiological measures to determine Depression type
Abstract: Depression affects about 20% of the population. Depression manifests in two main forms Bipolar Disorder (BD) and Major Depressive Disorder (MDD). At first consultation about 40% of BD patients are misdiagnosed, often as MDD. Giving the wrong medication to a depressive BD patient can produce Mania (significantly increasing risky behaviour including suicide etc.). Current techniques can take years to detect MDD from BD (particularly type II BD). Electrovestibulography (EVestG) can detect physiological differences at first consultation enabling identification of BD from MDD. For Biomedical Engineers it is critical to understand the underlying physiology in order to achieve optimal instrumentation and methodological design. This talk will introduce the methodology of EVestG, the complex Morel wavelet analysis of phase analysis used on the recordings then, using the Depression data, demonstrate relationships between the EVestG features, used to separate BD and MDD, and the underlying Depression physiology.
Bibliography: Professor Brian Lithgow is currently the Leader of the Diagnostic and Neurosignal Processing Research Groups at the Alfred Hospital (Melbourne, Australia) and Riverview Health Centre (Winnipeg, Canada). He is also a Senior Research Fellow at the Alfred Hospital and Research Affiliate at Riverview Health Center. His appointments include Adjunct Professor at the University of Manitoba, Canada and Adjunct Assoc. Professor at Monash Alfred Psychiatry Research Center. He founded the Monash University Centre for Biomedical Engineering (MUCBE) and was the Director of Teaching for MUCBE from 2001-2010.
Recent Research: Diagnostics development for neurological and neurodegenerative disorders: Dementia, Parkinson’s Disease, Vertiginous Disorders, Post-concussion syndrome, Bipolar disorder and Major Depressive disorder (4 patents).
- The successful quantitative separation of unipolar and bipolar depression is a world first.
- Current research aims at separating Dementia types and predicting treatment efficacy.
- An animal study is looking at modelling of vestibular electro-neurophysiology.
Publications: (>130 refereed publications, 6 books, 2 book chapters, 5 patents).